Directionality and Swimming Speeds in Predator-Prey and Male-Female Interactions of Euchaeta rimana, a Subtropical Marine Copepod

This examination showed how the sexual dichotomy in morphology and feeding was reflected in the swimming behavior of Euchaeta rimana. Nonrandom swimming was clearly exhibited by this copepod, and the evolutionary reasons for the behaviors involve the dual requirements of encountering food and mates. Mechanoreceptive females, with their enlarged feeding appendages and elongated antennal setae, must find prey to feed. Non-feeding males, with reduced mouthparts and antennal setules, must find females to inseminate before exhausting their lipid reserves which were accumulated during juvenile stages. Directional swimming by the female predatory copepod supports the predictions of models in which encounter rate was maximized by swimming orthogonally to their mates and their prey. The female swam horizontally in a turn-and-search pattern to intersect the male which swam vertically in a swim-up-and-sink pattern. Adult female copepods (~2.5 mm prosome length) generally swam smoothly and continuously at an average swimming speed of 7 mm's-I, with their antennae oriented into the flow not disturbed by their own movements. Besides mating, females also must find and capture prey. Analysis of swimming by one potential prey, Acartia fossae, showed that these smaller copepods darted up and stopped in various directions to counteract sinking due to gravity. This resulted in a strong vertical component to their directionality which increased the likelihood of encounter with the predatory copepod. The dart-and-stop swimming pattern of Acartia fossae may be an alternate mode of escape from a mechanoreceptive copepod, such as Euchaeta which can not sense prey when they are not moving

Enhancing Innovation Through Biologically Inspired Design

Mixing upper level undergraduates majoring in engineering with those majoring in biology, we have devised a course on biologically-inspired design (BID) that provides practical training in methods and techniques that facilitate the identification and translation of biological principles into solutions for human challenges. The challenges of interdisciplinary courses generally, and the specific challenges of fostering exchange among biologists and engineers lead us to define these learning goals: (1) basic knowledge of successful examples of BID, (2) interdisciplinary communication skills, (3) knowledge about domains outside of their core training, (4) a uniquely interdisciplinary design process, and (5) how to apply existing technical knowledge to a new discipline. We developed the following course components to meet the key learning objectives: BID Lectures; Design Lectures; Found object exercises; Quantitative assessments; Analogy exercises; Research assignments; Interdisciplinary Collaboration, Mentorship; Idea Journals and Reflections. We will provide an extensive description of these elements, which we have chosen to incorporate based on our own experience with interdisciplinary communication, as well as findings from cognitive science regarding how students actually learn. This 15 week course is organized using assignments of increasing complexity that allow students to learn and apply essential skills of BID methodology and practice. Early exercises, which combine lectures, group discussions and individual assignments, have these objectives: 1) allow students to develop the necessary inter-disciplinary communication and research skills to facilitate their design project work; 2) expose students to ideation and design skills that will encourage them to work outside of their comfort zone; 3) practice the analogical reasoning skills that facilitate the successful search for and application of relevant biological concepts. This initial portion of the course stresses that BID occurs at the early phase of a design process and that identifying solutions from the biological domain requires that students have a sufficient breakdown of their problem combined with sufficient biological knowledge to suggest appropriate mappings between problem and solution. Two primary barriers are a lack of appreciation for how the evolutionary “design” process differs from human design, and the use of different terminology for describing similar processes in biology vs. engineering. We describe some teaching practices and activities that allow students to overcome these difficulties. The course culminates in a group project, which is a detailed conceptual design including a preliminary analysis of expected performance, value, and feasibility. A unique feature of the course is that it represents the efforts of not only biologists and engineers, but also contributions from cognitive scientists engaged in understanding human cognition and creativity. Our course strategy has been deeply influenced by findings in that field. We have studied the activity of classroom participants for the last three years, examining the processes they use, and intermediate and final design representations. Analysis of this has yielded a number of observations about the cognitive process of biologically inspired design that may provide insights regarding how to enhance BID education, as well as provide useful insight for professionals in the design field. Key words: biologically-inspired design (BID); interdisciplinary communicatio

Evaluating Biological Systems for Their Potential in Engineering Design

A team of biologists, engineers, and cognitive scientists has been working together for the past five years, teaching an upper level undergraduate course in biologically inspired design where half the class of forty students are biologists and other physical scientists and the other half are engineers (mechanical, materials, industrial, others). From this experience, we provide insights on how to teach students to evaluate biological systems for their potential in engineering design. We have found that at first, students are not familiar with developing their own question since, in most engineering design classes, the problem is prescribed along with clients who would like to have them solved. In our class, we challenge the students with defining a significant problem. The students with common challenges then are placed together in an interdisciplinary team with at least one biologist and one engineer. A detailed problem decomposition follows, identifying the hierarchy of systems and clearly specifying functions. This is essential for the next step of analogical reasoning. Analogical reasoning as applied to BID is a process of matching biological functions to engineered functions and transferring functions and mechanisms from biology to engineering. For each desired function, students may ask: what mechanisms does nature use for achieving the function? This question guides the exploration of the wealth of knowledge in biology by asking them to clearly define the function of interest, then search for natural processes that perform this function. To expand on this search space, the students next make a list of the same function performed by other organisms for a comparative analysis to deepen their understanding and extract key biological principles. Students then invert the function and identify keywords to search. They also must refer to general biology books to identify key organisms that perform the function the best (and hence are included in textbooks). Using databases, such as the Web of Science functions, they can try to select the ‘best’ articles. If one is lucky, a single biological system may serve as a near perfect match to lead to a successful BID. However, some of the most innovative designs are built from more than one biological system, something that evolution cannot always do. We call these compound analogies. At this point, the design iteration can take on a different approach, namely solution based rather than problem based. Here, the team takes a natural system and asks, how can this biological principle improve an engineered design or function. These twin processes: solution vs problem-based approaches both have led to innovative and creative design concepts in this interdisciplinary class. Key words: Biological systems; engineering design; interdisciplinary clas

A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2

Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near WDR11-FGFR2 (P = 3.0 × 10−14) and provided suggestive evidence for a locus on chromosome 12 near OR8S1-LALBA (P = 1.2 × 10−7). Of the adiponectin-associated loci previously described, we confirmed the association at CDH13 (P = 6.8 × 10−165), ADIPOQ (P = 1.8 × 10−22), PEPD (P = 3.6 × 10−12), CMIP (P = 2.1 × 10−10), ZNF664 (P = 2.3 × 10−7) and GPR109A (P = 7.4 × 10−6). Conditional analysis at ADIPOQ revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (Pinitial = 0.020; Pconditional = 7.0 × 10−7). We further confirmed the independence of two pairs of closely located loci (<2 Mb) on chromosome 16 at CMIP and CDH13, and on chromosome 12 at GPR109A and ZNF664. In addition, the newly identified signal near WDR11-FGFR2 exhibited evidence of association with triglycerides (P = 3.3 × 10−4), high density lipoprotein cholesterol (HDL-C, P = 4.9 × 10−4) and body mass index (BMI)-adjusted waist–hip ratio (P = 9.8 × 10−3). These findings improve our knowledge of the genetic basis of adiponectin variation, demonstrate the shared allelic architecture for adiponectin with lipids and central obesity and motivate further studies of underlying mechanisms

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.Peer reviewe

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead